Tuesday, 14 May 2013

Malaria Facts


Name of disease

Malaria
Name of causative agent

Plasmodium parasite
Type of microbe

Eukaryote

If Bacterial:

The bacteria that causes Malaria is called Plasmodium
·         Gram-reaction

Typically, smears for malarial parasites are stained using the same stains as for blood smears. They are not bacteria, they are intracellular parasites.
·         Cell shape and arrangement

Transportation into the cell, secretion, diffusion and reproduction. Cell shape is rod like.
(Malaria is an acute febrile illness)
If Eukaryotic:

Protozoa
There are four different species ; Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malaria
·         Multicellular or Unicellular

Unicellular
(acellular intracellular parasites)
Egg sac ruptures and releases cells called sporozoites which travel to the salivary glands. Sporozites enter the bloodstream with mosquito bite and travel to the liver. Then
develops in liver cells, which change form and invade red blood cells.
If Viral:

Cardiovascular & Lymphatic disease -  Parasitic Disease
·         Naked or Enveloped

Malaria is a vector-borne infectious disease caused by a eukaryotic protist of the immune system's ability to fight viral infection.
·         Formation of Provirus

parasitic infection on the development of a lymphotropic virus
Epidemiology:


·         Geographic Prevalence

Over 100 countries with tropical and subtropical regions are affected; Africa, South & Central America, Hispaniola, Oceania, Asia & the Middle East
·         Average rates of infection

R=0 no. Zero. N/A – Infection very possible if a person visits a country with malarious areas, having had no anti-malarial drugs beforehand
·         Reservoir(s)

Humans, Anopheles mosquitoes, animals such as monkeys and birds
·         Main transmission mode(s)

Bite from a female Anopheles mosquito causes infected saliva to enter the bloodstream and multiply
Pathology:


·         Major tissues/organs affected

Brain, Lungs, Kidneys, Placenta and other tissues.
·         Major signs/symptoms

Anaemia, pain in joints, fever, chills, nausea and flu like symptoms. Light headed, shortness of breath and in severe cases death.
·         Sequalae

Lack of information on duration of disease sequalae such as anaemia and for
Neurological disorders due to complicated malaria.
·         Latency

7 days or more, usually 10-15 days
Treatment:


·         Main treatment methods

Uncomplicated Malaria: Quinine followed by Doxycycline, Clindamycin or Sulfadoxine with Pyrimethamine
Severe Malaria: Quinine administered intravenously directly into the bloodstream
·         Typical length of treatment

Varies, dependant on the area in which the patient became infected, the type of malaria, severity of illness and also any complications.
·         Prophylactic measures

Research the country you are visiting beforehand to establish if the area is malarious, take anti-malarial drugs such as Chloroquine or Proguanil before during and after the visit, use insect repellent containing DEET (diethyltoluamide), cover exposed skin, sleep under a bed net and sleep in an air conditioned room


Reference
https://www.youtube.com/watch?v=QwEkGCjbbJ8

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